USPTO Patents Application 09839649

Atty. Docket No.: 22620/1222

PATENT

IN THE UNITED STATES PATENT AND TRADEMARK OFFICE fpf

S. Chundug

Application of: / Murchie, et al.
Serial No.: ( 09/839,649
Filed: v April 19, 2001

Entitled: "Assay for Identification of a Test

Compound"

Examiner:
Group Art Unit: 1637

Conf.No.: 2120

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CD

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CERTIFICATE OF MAILING UNDER 37 CF.R. SL8a ET

I hereby certify that this correspondence (and any paper or fee referred to as being enclosed) is being
deposited with the United States Post Office as First Class Mail on the date indicated below in an envelope !
addressed to Box: AF Commissioner for Patents, Washington, D.C. 2023 1 .

v v Mary Wilson

Box: AF

Commissioner for Patents
Washington, D.C. 20231

Signatureg^rgfson Mailing Paper

AMENDMENT AND RESPONSE TO FINAL OFFICE ACTION

Sir:

This is filed in response to the Final Office Action mailed November 19, 2002 in
the above-noted U.S. Patent Application. Kindly enter the following proposed

Amendments and Remarks.

In the Claims:

Please replace claim 1 with the following amended claim 1 .

1 . (Amended) A method for determining whether a test compound binds to a target
RNA, the method comprising the steps of:

(a) contacting said test compound with said target RNA and an RNA-modifying enzyme
that covalently alters an existing base in said target RNA; and

(b) detecting the modification of said target RNA by said enzyme and comparing the
amount of modification detected to that of a standard, wherein said comparing determines
whether said test compound binds to said target RNA.

1

TECH CENTER 16QQ/23G0

Atty. Docket No.: 22620/1222

PATENT

IN THE UNITED STATES PATENT AND TRADEMARK OFFICE

pplication of: ; Murchie, et al.
Serial No.: ^09/839,649
Filed: April 19,2001

Entitled: "Assay for Identification of a Test

Compound"

Examiner: S. Chunduru

Group Art Unit: 1637

Conf. No.:

2120

CERTIFICATE OF MAILING UNDER 37 C.F.R. S 1.8a

I hereby certify that this correspondence (and any paper or.fee referred to as being_ehclosed) is being^
deposited with the United States Post Office as First Class Mafl^ontiie^date indited below in an envelope
addressed to Box: AF, Commissioner for Patents, Washington, D.C. 2023 1 .

Mary Wilson

Name<

j$x\ Mailing Paper

Signature of Person Mailing Paper

Box: AF

Commissioner for Patents
Washington, D.C. 20231

TRANSMITTAL LETTER

Enclosed for filing in the above-identified patent application, please find the following
documents:

1. Response to Final Office Action mailed November 19, 2002;

2. Petition for One Months' Extension of Time;

3. Check in the amount of $55.00 for the requisite fee; and

4. Return Post Card.

The Commissioner for Patents is hereby authorized to charge any additional fees or credit
any overpayment in the total fees to Deposit Account No. 16-0085, Reference No. 22620/1222.
A duplicate of this transmittal letter is enclosed for this purpose.

Respectfully submitted, g ^ 4£ fl? A-

Date: March 17, 2003

Name: K^hleen Williams
Registration No.: 34,380
Customer No.: 29933
Palmer & Dodge LLP
111 Huntington Avenue
Boston, MA 02199-7613
Tel: 617-239-0100

RECEIVED

MAR 2 7 2003

TECH CENTER 1600/2900

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